dr hab. Anna Malik adiunkt
Wydział Biologii
Dyscyplina naukowa:
nauki biologiczne
Zainteresowania badawcze:
Prace badawcze prowadzone przez Grupę BAadawczą Neurobiologii Komórkowej obejmują mechanizmy komórkowe istotne dla rozwoju chorób mózgu. Skupiamy się przede wszystkim na aktywności komórek glejowych (głównie astrocytów i mikrogleju) oraz makrofagów w kontekście udaru niedokrwiennego, choroby Alzheimera oraz glejaka wielopostaciowego. Prowadzimy badania w modelach in vitro (m.in. hodowle pierwotne komórek mózgu i makrofagów) oraz in vivo (operacje stereotaktyczne, myszy transgeniczne). We współpracy z grupą obliczeniową IPI PAN prowadzimy także analizy bioinformatyczne, m.in. danych z doświadczeń scRNAseq.
description of research interests:
Research conducted by the Cellular Neurobiology Research Group focuses on the cellular mechanisms important for the pathogenesis of brain diseases. We focus primarily on the activity of glial cells (mainly astrocytes and microglia) and macrophages in the context of ischemic stroke, Alzheimer's disease and glioblastoma multiforme. In our work, we use in vitro models (including primary cultures of brain cells and macrophages) and in vivo model (stereotactic surgeries, transgenic mice). In cooperation with the IPI PAN, we also perform bioinformatic analyses such as scRNAseq data analysis.
Realizowane projekty:
Granty badawcze:
2023 Research grant Clonal Haematopoiesis in Ischemic Stroke in frame of ERA-NET NEURON, Call for transnational research projects 2022, Cerebrovascular Diseases including Small Vessels and Brain Barriers Dysfunction. Consortium member. https://www.neuron-eranet.eu/projects/CH-Stroke/;
2022 Funding in frame of Initiative of Excellence – Research University action ‘Creation of three research teams that will initiate development of scientific networks conducting studies in the area of civilization diseases, emerging pollutants and circular economy’. Project PI.
2021 Research grant VPS10P domain receptors in phenotypic polarization of astrocytes and microglia in the diseased brain awarded by National Science Center in frame of Opus program; 2020/37/B/NZ3/00761. Project PI.
research projects implemented:
Research grants:
2023 Research grant Clonal Haematopoiesis in Ischemic Stroke in frame of ERA-NET NEURON, Call for transnational research projects 2022, Cerebrovascular Diseases including Small Vessels and Brain Barriers Dysfunction. Consortium member.https://www.neuron-eranet.eu/projects/CH-Stroke/;
2022 Funding in frame of Initiative of Excellence – Research University action ‘Creation of three research teams that will initiate development of scientific networks conducting studies in the area of civilization diseases, emerging pollutants and circular economy’. Project PI.
2021 Research grant VPS10P domain receptors in phenotypic polarization of astrocytes and microglia in the diseased brain awarded by National Science Center in frame of Opus program; 2020/37/B/NZ3/00761. Project PI.
Słowa kluczowe:
neurobiologia, glej, glejak, udar niedokrwienny, choroba Alzheimera, transport wewnątrzkomórkowy
Słowa kluczowe:
neurobiology, glia, glioma, ischemic stroke, Alzheimer's disease, intracellular transport
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